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1–2 jobs· newest first

Principal Research Scientist - Medicinal ChemistNew
Elanco · Indianapolis, US
Hybrid · Full-time · Principal
Senior Scientist I, Biotherapeutic Production Technologies
Generate Biomedicines · Andover, US
$125K–$175KOn-site · Full-time · Senior

+10K new in the last hour

Principal Research Scientist - Medicinal Chemist

Elanco · Posted Nov 9, 2026

Indianapolis, Indiana, United States
Hybrid
Full-time · Principal
8–10 years

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Lead medicinal chemistry initiatives within multidisciplinary teams, driving design, synthesis, and optimization of small molecules for animal health drug discovery.

Responsibilities

Drive the design and optimization of novel small molecules
Lead medicinal chemistry initiatives within multidisciplinary teams
Serve as a key medicinal chemistry figure on multidisciplinary project teams
Direct synthetic chemistry efforts with external CROs and internal partners
Leverage cutting-edge drug discovery technologies

Requirements

PhD in Medicinal Chemistry, Organic Chemistry, or a related scientific discipline
Nice to have: postdoctoral experience
Nice to have: modern drug discovery technologies such as DEL, computational chemistry, or AI/ML-enabled molecular design
Nice to have: strong track record of advancing small-molecule discovery programs toward preclinical development
Nice to have: prior research experience in the animal health industry

Skills

modern medicinal chemistry design and multi-step synthesis of complex small molecules structure-activity relationships (SAR)pharmacology ADME/PK principles synthetic strategies AI/ML DNA-Encoded Libraries (DEL)computational chemistry AI/ML-enabled tools

Benefits

Multiple relocation packages
Two weeklong shutdowns (mid-summer and year-end) in the US
8-week parental leave
9 Employee Resource Groups
Annual bonus offering

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Senior Scientist I, Biotherapeutic Production Technologies

Generate Biomedicines · Posted Nov 3, 2026

Andover, Massachusetts, United States
On-site
Full-time · Senior
$125K–$175K per year
4+ years

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Lead complex protein production, purification, and characterization efforts in support of drug discovery and platform initiatives.

Compensation

$125,000—$175,000 USD

Responsibilities

Define and execute complex protein production, purification, and characterization strategies across multiple discovery and platform initiatives
Lead design, optimization, scale-up, and troubleshooting of protein expression workflows, including transient mammalian and cell-free platforms
Develop purification workflows from capture through polishing, including chromatography screening and scale translation
Produce high-quality protein material across a range of formats and scales
Select, apply, and interpret analytical and biochemical characterization methods

Requirements

Ph.D. in biochemistry, molecular biology, bioengineering, chemical engineering, protein sciences, or a related discipline
B.S. or M.S. in a relevant scientific or engineering discipline
Nice to have: stable-expression systems
Nice to have: stable cell-line development
Nice to have: engineered proteins

Skills

protein production protein purification

protein characterization

mammalian expression

cell-free expression

analytical chemistry

molecular biology

stable-expression systems

construct design

high-throughput experimentation

laboratory information systems

structured experimental-data environments

CDMO management

vendor management

chromatography screening

predictor-plate approaches

resin selection

operating-condition optimization

AI/ML-enabled tools

Benefits

competitive benefits package
annual bonus
equity compensation

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