CRISPR Therapeutics is seeking a Clinical Pharmacology Lead to join us in developing novel gene therapies for serious diseases. This hands-on role spans clinical pharmacology strategy, dose selection, PK/PD analysis, bioanalytical assay strategy, liaising with SMEs for technical development of assays, CRO management, timely data delivery in support of clinical trials, and authoring relevant sections of publication/regulatory submissions.
Locations (4)
South Boston, Massachusetts, United States
Boston, Massachusetts, United States
San Francisco, California, United States
Zug, Zug, Switzerland
Compensation
Senior Manager: Base pay range of $135,000 to $150,000+ bonus, equity and benefits
Responsibilities
Serve as the clinical pharmacology lead on cross-functional program teams, owning clinical pharmacology strategy from IND through later-stage development.
Drive dose selection and justification by integrating nonclinical, translational, and emerging clinical data.
Design PK, PD, and biomarker sampling strategies for clinical protocols in partnership with clinical development, bioanalytical, and clinical operations colleagues.
Collaborate with clinical operations and clinical sample operations to inform domestic and international sample journey plans and contribute to appropriate clinical laboratory manuals.
Translate the needs of the clinical program into a portfolio of clinical assays and vendor strategies via collaboration with discovery/pre-clinical scientists, clinical scientists and commercial vendors.
Requirements
BS in pharmacology, pharmaceutical sciences, pharmacometrics, biomedical engineering, or a related field
PhD, PharmD, or equivalent in pharmacology, pharmaceutical sciences, pharmacometrics, biomedical engineering, or a related field
Nice to have: Assay development and validation across molecular (qPCR, NGS), protein (ELISA, MSD, Luminex, HPLC), and immunological (multiparameter flow cytometry, immunohistochemistry) platforms