- Cambridge, Cambridgeshire, United Kingdom
- On-site
- Full-time · Senior
As a Senior Scientist in Biophysics, your mission is to apply deep biophysical binding characterization expertise—predominantly leveraging Surface Plasmon Resonance (SPR)—to interrogate novel Bicycle molecules, unpick complex molecular interactions, and triage screening cascades.
Compensation
Competitive reward including annual company bonus
Responsibilities
- Design, optimize, and perform robust biophysical binding assays (predominantly SPR) for the kinetic and affinity characterization of Bicycle peptides, conjugates, and molecular targets.
- Deliver high-quality, reproducible data with in-depth analysis and insightful kinetic interpretation to triage screening cascades and inform lead optimization.
- Drive exploratory investigations and tailor bespoke biophysical assay formats for novel and historically challenging therapeutic targets.
- Explore, implement, and validate orthogonal biophysical technologies (e.g., Carterra high-throughput SPR, AlphaScreen, DSF, FP, HTRF, or mass photometry) to broaden the lab's screening capabilities.
- Partner with computational and structural biology teams to integrate biophysical datasets into Structure-Based Drug Design (SBDD) and AI-driven platform workflows.
Requirements
- Nice to have: Carterra
- Nice to have: AlphaScreen
- Nice to have: DSF
- Nice to have: FP
- Nice to have: HTRF