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Principal Scientist, Biotherapeutic Formulations

Halozyme, Inc. · Posted Nov 5, 2026

San Diego, California, United States
On-site
Full-time · Principal
$170K–$200K per year
10+ years

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Provide scientific and technical leadership for the formulation development and characterization of partner biotherapeutics using the company’s proprietary excipient and spray-drying platform.

Responsibilities

Lead formulation development for platform and partner molecules using the company’s proprietary excipient and spray-drying technology.
Develop, optimize, and characterize formulations from feedstock through spray drying, powder generation, and final high-concentration suspensions, ensuring molecular stability, product quality, manufacturability, and performance.
Design and execute stability studies to understand the effects of formulation composition, processing conditions, concentration, storage conditions, and time on product quality and performance.
Perform and interpret biophysical characterization of biologic feedstocks, formulation intermediates, spray-dried powders, and final suspensions to understand degradation pathways, physical stability, and formulation performance.
Independently develop experimental hypotheses, study designs, protocols, and data-analysis approaches, including DOE methodologies.

Requirements

PhD in a scientific discipline
Pharmaceutical Sciences
Materials Science
Chemical Engineering
Nice to have: chromatography

Skills

biologics formulation development

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DRAM Pathfinding & Process Integration Engineer

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Principal Scientist, Biotherapeutic Formulations

Responsibilities

Requirements

Skills

Benefits

DOE methodologies jobs

Compensation

Responsibilities

Requirements

Skills

Benefits

Responsibilities

Requirements

Skills

Benefits