Support the production of therapeutic proteins in a GMP manufacturing environment, operating production equipment and executing downstream purification processes.
Compensation
Compensation programs that recognize high performance
Responsibilities
Set up, operate, and monitor manufacturing equipment, including purification systems, CIP, and SIP processes
Execute downstream manufacturing operations, including chromatography, filtration, and product processing activities
Support column packing, viral reduction filtration, and other purification-related operations
Perform laboratory tasks such as pH testing, conductivity testing, and product sampling
Move and transfer materials across production areas safely and accurately
We are seeking a highly motivated Principal Scientist I with extensive AAV gene therapy manufacturing experience to develop state‑of‑the‑art downstream purification processes for next‑generation AAV gene therapy.
Compensation
The salary for this position is expected to range between $108,500 and $201,500 per year for Principal Scientist I, and between $119,700 and $222,300 per year for Principal Scientist II. The final salary offered is determined based on factors like, but not limited to, relevant skills and experience, and upon joining Novartis will be reviewed periodically. Novartis may change the published salary range based on company and market factors.
Responsibilities
Lead and manage a 3-5 person downstream process team and provide technical support, training, and SME knowledge to assist with the professional development of direct reports.
Coordinate activities with associates across upstream process and analytical teams.
Develop strategies in collaboration with Disease Areas and partner with various line functions to support early drug discovery from target selection and validation through lead compound selection and developability assessment.
Serve as a subject matter expert to transfer manufacturing process knowledge to Technical Research & Development team and advance pipeline programs into clinical phases.
Lead effort and work collaboratively with Technical Research & Development to develop innovative and cost‑effective downstream processes for next‑generation AAV.
Requirements
PhD in bioprocessing, biochemical engineering, gene therapy or a related field
Lead and manage a downstream process team to develop purification processes for next-generation AAV gene therapy and execute early-stage process development.
Compensation
The salary for this position is expected to range between $108,500 and $201,500 per year for Principal Scientist I, and between $119,700 and $222,300 per year for Principal Scientist II.
Responsibilities
Lead and manage a 3-5 person downstream process team and provide technical support, training, and SME knowledge to assist with the professional development of direct reports.
Coordinate activities with associates across upstream process and analytical teams.
Develop strategies in collaboration with Disease Areas and partner with various line functions to support early drug discovery from target selection and validation through lead compound selection and developability assessment.
Serve as a subject matter expert to transfer manufacturing process knowledge to Technical Research & Development team and advance pipeline programs into clinical phases.
Lead effort and work collaboratively with Technical Research & Development to develop innovative and cost-effective downstream processes for next-generation AAV.
Requirements
PhD in bioprocessing, biochemical engineering, gene therapy or a related field