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1–2 jobs· newest first

Scientist I/II, Investigative ToxicologyNew
ICONMA, LLC · South San Francisco, US
On-site · Full-time · Associate
Director, Head of Investigative Toxicology
Nurix · Brisbane, US
$240K–$282KOn-site · Director

+10K new in the last hour

I

Scientist I/II, Investigative Toxicology

ICONMA, LLC · Posted Nov 9, 2026

South San Francisco, California, United States
On-site
Full-time · Associate
1+ years

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Elucidate the mechanisms underlying toxicities observed non-clinically and/or in clinical trials through hypothesis driven research, supporting safety assessment for novel therapeutics.

Responsibilities

Culturing and expanding primary cells and cell lines for in vitro screenings
Performing assays including cytotoxicity and metabolic changes of cells
Capturing cell culture images using high content imaging, flow cytometry
Making detailed observations related to experiments and interpreting results
Contributing scientific insights and working on peer review publications

Requirements

Bachelors (BS/BA) in pharmacology, pharmaceutical science, biology, bioengineering, chemistry, physiology, or related discipline
Nice to have: Experience with complex in-vitro model systems

Skills

Lab experience Culturing mammalian cells Hypothesis-driven research Cell viability assessment Luminex/ELISAs Gene expression analysis High content screening Confocal microscopy Flow cytometry High content imaging

Benefits

Health Benefits
Referral Program
Excellent growth and advancement opportunities

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Director, Head of Investigative Toxicology

Nurix · Posted Nov 5, 2026

Brisbane, California, United States
On-site
Director
$240K–$282K per year
10+ years

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Lead the development of an in‑vitro toxicology platform, build assays, manage lab operations, and provide mechanistic insights to support drug discovery.

Compensation

Salary Range: $240,100 - $281,700

Responsibilities

Design, establish, and validate an in‑vitro toxicology testing platform
Develop and implement in‑vitro toxicology assays
Define technical roadmap and prioritize in‑house vs CRO sourcing
Own day‑to‑day lab operations
Serve as toxicology representative on discovery project teams

Requirements

PhD in Toxicology, Pharmacology, Molecular Biology, or a closely related life sciences discipline
Nice to have: targeted protein degradation (TPD)
Nice to have: novel small molecule modalities
Nice to have: NAMs
Nice to have: organ‑on‑chip/microphysiological systems

Skills

in vitro toxicology assay development cell culture hepatocyte models iPSC cardiomyocyte models

high content imaging

genotoxicity assays

CRO relationship management

build‑versus‑buy decision making

mechanistic toxicology

primary and immortalized cell culture

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