- Waltham, Massachusetts, United States
- On-site
- Full-time · Associate
- 3+ years
Responsible for assay optimization, qualification, and validation, and technology transfer for proteins and other biomolecules.
Responsibilities
- Assay optimization, qualification, and validation, and technology transfer for proteins and other biomolecules
- Method development for identity, purity, aggregation status, charge isoforms, and potency using chromatography and electrophoresis
- Support upstream and downstream process development in-process testing, drug substance/drug product release testing, and stability study testing
- MS analysis of intact proteins and fragments generated by various enzyme digestion; peptide mapping analysis by LC-MS
- Generate, manage, evaluate, and maintain data in a highly organized manner
Requirements
- Bachelor’s or Master’s degree in Chemistry, Biochemistry, Pharmaceutical Sciences, or a related field
- Nice to have: Enzyme protein and mAb intact mass analysis
- Nice to have: Glycan analysis by LCMS
- Nice to have: Understanding of mAb and protein molecular and biochemistry
- Nice to have: Understanding of post-translational modifications