Biophysical characterization jobs

Senior Scientist I, Biologics Drug Product Development

AbbVie · Posted Nov 12, 2026

Open

North Chicago, Illinois, United States
Full-time · Senior
8–4 years

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Senior Scientist I, Biologics Drug Product Development

AbbVie · Posted Nov 12, 2026

Open

North Chicago, Illinois, United States
Full-time · Senior
8–4 years

Apply with Referso

Research Associate (Limited Term, 2 years)

University of Toronto · Posted Nov 12, 2026

Open

Toronto, Ontario, Canada
Full-time
CA$56K–CA$104K per year
2–4 years

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Lead and manage advanced research projects in nucleic acid therapeutics and non-viral delivery, overseeing experimental design, grant development, and publication efforts.

Compensation

Pay Scale Group & Hiring Zone: R01 -- Research Associates (Limited Term): $55,661 - $104,364

Responsibilities

Conduct advanced academic research to achieve the research goals of the PI and lab, focusing on non-viral nucleic acid delivery, CRISPR-mediated gene targeting, and therapeutic mRNA/tRNA applications
Independently conceptualize, design, and lead experimental studies in CRISPR/Cas9 site-specific gene integration, homology-directed repair optimization, and functional phenotypic rescue
Formulate, optimize, and characterize lipid nanoparticles (LNPs) and delivery vectors, establishing analytical and quality control assays for RNA encapsulation, biophysical properties, and stability
Oversee and execute translational disease model pipelines, including air-liquid interface (ALI) cultures of primary airway epithelial cells, organoids, and preclinical rodent models
Lead the interpretation and dissemination of research findings through high-impact, peer-reviewed scientific publications

Requirements

Ph.D. in Laboratory Medicine and Pathobiology, Molecular Genetics, Pharmaceutical Sciences, Biomedical Engineering, Biochemistry, or a closely related biomedical discipline

Principal Scientist (m/f/d) Protein Engineering

BoehringerPRD · Posted Nov 12, 2026

Open

Vienna, Vienna, Austria
Full-time · Senior
€91K–€91K per year
3–5 years

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Lead and mentor a team of scientists, driving the design, engineering, and optimization of next-generation therapeutic proteins, including multispecific antibodies and other innovative biologic modalities.

Compensation

The remuneration for this position starts at EUR 90.900 gross annual target salary per year (full time).

Responsibilities

Lead and mentor a team of scientists, ensuring high standards of laboratory safety, data quality, and professional development.
Drive the design, engineering, and optimization of multispecific antibodies and other therapeutic proteins, applying innovative protein engineering strategies.
Provide scientific and project leadership across portfolio projects, managing multidisciplinary teams from exploratory research through candidate selection.
Collaborate with Oncology scientists, internal experts, and external partners to translate emerging biological insights into differentiated protein-based therapeutic concepts.
Apply protein engineering expertise, leveraging computational, structural, and data-driven approaches to optimize activity, selectivity, stability, expression, and developability.

Requirements

PhD in Protein Engineering, Biochemistry, Biotechnology, or a related field

Skills

Protein engineering

PDRA

Durham University · Posted Nov 10, 2026

Open

Durham, Durham, United Kingdom
On-site
Full-time · Mid
Full-time for 15 months.

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Post-Doctoral Research Assistant at the Centre for Programmable Biological Matter focusing on the development of engineered protein nanocages for the delivery of molecular cargoes to mitochondria.

Responsibilities

Understand and convey material of a specialist or highly technical nature to the team or group of people through presentations and discussions
Prepare and deliver presentations on research outputs/activities
Publish high quality outputs, including papers for submission to peer reviewed journals and papers for presentation at conferences
Assist with the development of research objectives and proposals
Conduct individual and collaborative research projects

Requirements

Nice to have: mitochondrial genetics
Nice to have: nanotechnology
Nice to have: extracellular vesicle engineering

Skills

protein engineering AI-enabled protein design synthetic biology recombinant protein production biophysical characterization

Principal Scientist, Formulation & Drug Product Development

Denali Therapeutics · Posted Sep 10, 2026

Open

South San Francisco, California, United States
On-site
Full-time · Principal
$159K–$207K per year
10+ years

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Serve as a formulation and drug product process development lead for a growing portfolio of protein biologics, providing technical formulation and drug product expertise across the development lifecycle.

Compensation

Salary Range: $159,000.00 to $207,000.00 . Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience.

Responsibilities

Independently drive formulation and drug product development activities for large molecule biotherapeutics
Design and execute formulation development studies to identify clinical and commercial formulation & dosage form, establish shelf life of DS & DP, assess in-use compatibility, and support comparability assessments
Develop stress comparability strategies to support process changes and scale-up
Oversee drug product process development activities as well as DP process characterization and process validation activities to support clinical and commercial manufacturing
Perform biophysical and biochemical characterization of protein therapeutics in the laboratory using chromatography-, capillary-, spectroscopy-based analytical methods

Requirements

PhD in Chemical Engineering
PhD in Pharmaceutical Sciences
PhD in Biophysics
PhD in Analytical Chemistry
BS or MS with commensurately greater directly relevant experience

Skills

Spring 2027 Co-Op, Structural Biology & Biophysics

Vertex Pharmaceuticals · Posted Nov 5, 2026

Open

Boston, Massachusetts, United States
On-site
Contract · Intern
$20–$35 per hour

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Support laboratory activities and research projects within the Structural Biology and Biophysics team, performing routine laboratory techniques and contributing to experiments that characterize proteins and assess molecular interactions.

Compensation

Full-time, paid co-op $20.00-35.00 USD/hour

Responsibilities

Support daily laboratory activities and research projects within the Structural Biology and Biophysics team.
Learn and perform routine laboratory techniques under the guidance of experienced scientists.
Prepare buffers, reagents, samples, and assay plates by following established procedures.
Support biochemical and biophysical assay activities, including nephelometry-based experiments used to evaluate properties such as sample solubility, aggregation, or precipitation.
Collect, organize, and document experimental data using laboratory notebooks, electronic systems, spreadsheets, and reports.

Requirements

Bachelor's or Master's degree in biochemistry, biology, chemistry, biotechnology, biophysics, molecular biology, pharmaceutical sciences, or a related scientific field
Nice to have: prior experience in structural biology, biophysics, or pharmaceutical research
Nice to have: prior exposure to structural biology and/or biophysics through coursework, academic research, laboratory projects, internships, or scientific literature review
Nice to have: familiarity with nephelometry, turbidity measurements, microplate-based assays, plate readers, or laboratory automation

Spring 2027 Co-Op, Structural Biology & Biophysics

Vertex Inc. · Posted Nov 5, 2026

Open

Boston, Massachusetts, United States
On-site
Contract · Intern
$20–$35 per hour

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Support laboratory activities and research projects within the Structural Biology and Biophysics team, performing experimental work and data documentation.

Compensation

Full-time, paid co-op $20.00-35.00 USD/hour

Responsibilities

Support daily laboratory activities and research projects within the Structural Biology and Biophysics team.
Learn and perform routine laboratory techniques under the guidance of experienced scientists.
Prepare buffers, reagents, samples, and assay plates by following established procedures.
Support biochemical and biophysical assay activities, including nephelometry-based experiments used to evaluate properties such as sample solubility, aggregation, or precipitation.
Collect, organize, and document experimental data using laboratory notebooks, electronic systems, spreadsheets, and reports.

Requirements

Bachelor's or Master's degree in biochemistry, biology, chemistry, biotechnology, biophysics, molecular biology, pharmaceutical sciences, or a related scientific field
Nice to have: prior experience in structural biology, biophysics, or pharmaceutical research
Nice to have: prior exposure to structural biology and/or biophysics through coursework, academic research, laboratory projects, internships, or scientific literature review

Senior Scientist I, Biologics Drug Product Development

Senior Scientist I, Biologics Drug Product Development

Responsibilities

Requirements

Skills

Benefits

Research Associate (Limited Term, 2 years)

Compensation

Responsibilities

Requirements

Principal Scientist (m/f/d) Protein Engineering

Compensation

Responsibilities

Requirements

Skills

PDRA

Responsibilities

Requirements

Skills

Principal Scientist, Formulation & Drug Product Development

Compensation

Responsibilities

Requirements

Skills

Spring 2027 Co-Op, Structural Biology & Biophysics

Compensation

Responsibilities

Requirements

Spring 2027 Co-Op, Structural Biology & Biophysics

Compensation

Responsibilities

Requirements

Skills

Skills

Benefits

Benefits

Skills

Benefits

Benefits