Principal Scientist, Biology
Rgenta Therapeutics · Posted Nov 6, 2026
- Woburn, Massachusetts, United States
- On-site
- Full-time · Principal
- 5–8 years
The Principal Scientist, Biology will lead in vitro and in vivo activities to identify and evaluate target dependency hypotheses, help identify preclinical models representative of target patient populations, lead biomarker strategy, and validate small molecule series.
Responsibilities
- Serve as a Biology lead on cross‑functional teams passionate about advancing small molecule drug discovery programs
- Manage internal research activities and external CRO partnerships to drive projects forward with high‑quality, decision‑enabling data
- Develop and validate cell‑based models to support lead optimization and pharmacology profiling
- Help identify preclinical models that are representative of target patient populations
- Evaluate drug mechanism of action, as well as response and resistance, in clinically relevant models
Requirements
- Ph.D. with postdoctoral training in genetics, cell biology, molecular biology, or a related field