- San Diego, California, United States
- On-site
- Full-time · Senior
- 3–4 years
Seeking a highly motivated Ocular Research Scientist to support the discovery and preclinical development of innovative therapies for retinal diseases, focusing on ocular biology, retinal disease models, and translational research.
Responsibilities
- Lead and participate in research efforts to discover, characterize, and validate novel approaches for extrahepatic siRNA and RNA editing activities, with a focus on ophthalmology targets.
- Develop, optimize, and characterize ocular mouse models relevant to AMD including Geographic atrophy (dry AMD), neovascular or wet AMD, diabetic retinopathy and diabetic macular edema, retinal vascular leakage and neovascularization, inherited and rare retinal diseases, retinal inflammation, and neurodegeneration.
- Establishment of ocular in vivo systems to screen siRNAs via ocular dosing and administration in rodents, including intravitreal, subretinal, topical, periocular, and systemic delivery, as appropriate for the study.
- Perform animal monitoring, clinical observations, study scheduling, tissue collection, necropsy procedures, and sample processing in accordance with approved protocols.
- Conduct detailed microdissection of ocular tissues, including isolation of the retina, RPE/choroid, optic nerve, vitreous, aqueous humor, and other relevant ocular compartments.
Requirements
- Ph.D. in Neuroscience
- Ophthalmology/Vision Science
- Molecular Biology
- Cell Biology
- Pharmacology