- South San Francisco, California, United States
- On-site
- Full-time · Senior
- 1+ years
Design, execute, and optimize E. coli fermentation processes from shake flask through bench-scale and pilot-scale bioreactors, owning the experimental work hands‑on.
Compensation
Cogent Scientific offers competitive pay, attractive benefits (such as medical/dental/vision insurance; 401(k); parental leave; PTO and paid holidays; etc.)
Responsibilities
- Design, execute, and optimize E. coli fermentation processes from shake flask through bench-scale and pilot-scale bioreactors, owning the experimental work hands‑on.
- Drive measurable improvements in yield and batch‑to‑batch consistency through systematic optimization of host strain performance, media composition, feed strategy, induction conditions, and control setpoints for pH, dissolved oxygen, temperature, and agitation.
- Using design of experiments, define the process design space and identify the critical process parameters that govern product quality and quantity, rather than relying on one‑factor‑at‑a‑time work.
- Establish scale‑independent criteria (volumetric power input, oxygen transfer capacity, mixing time, and gas‑phase mass balance) so that performance demonstrated at bench scale is reproducible at pilot scale and beyond.
- Develop clear, pre‑specified experimental plans, analyze and interpret the resulting data with appropriate statistical rigor, and present conclusions and recommendations to cross‑functional teams and leadership.