- Waltham, Massachusetts, United States
- Full-time · Mid
- $125K–$165K per year
- 3+ years
Engineer and optimize gene editing proteins using machine learning, protein language models, and laboratory research.
Compensation
The budgeted range for this position is $125,000 - $165,000.
Responsibilities
- Carry out directed evolution campaigns to improve activity and specificity of gene editing proteins.
- Generate protein libraries and variants through molecular cloning, mutagenesis, and related engineering approaches.
- Design and engineer gene editing proteins using sequence and structural analysis, machine learning, and protein models.
- Develop and execute iterative cycles that connect computational predictions with experimental results.
- Develop and perform biochemical and cell-based assays to evaluate gene editing efficiency, specificity, and performance.
Requirements
- Ph.D. in scientific discipline
- M.S. with at least 10 years of relevant experience
- Nice to have: engineering or characterizing gene editing systems
- Nice to have: CRISPR-associated nucleases
- Nice to have: base editors