Lead in vivo pharmacology studies for anti‑obesity therapeutics in a preclinical discovery setting.
Compensation
Pay: $47.00/hr - $57.00/hr based on experience and academia
Responsibilities
Plan and independently execute in vivo experiments to support preclinical characterization and evaluation of targets/pathways that regulate energy balance.
Perform routine rodent handling, dosing via multiple routes of administration (including but not limited to PO, IP, SQ, IV), blood collection (including cardiac puncture), perfusion, and tissue collection.
Conduct metabolic assessments, including food intake measurements, glucose tolerance tests (GTT), and insulin tolerance tests (ITT).
Perform molecular and biochemical assessments on ex vivo samples.
Maintain accurate records, independently analyze data, and report data in written and oral formats.
Requirements
B.S. and/or M.S. in biology or a closely related field
Nice to have: background in biology and physiology of energy balance regulation and metabolic disease
Nice to have: immunohistochemistry
Nice to have: brain sectioning
Nice to have: confocal or fluorescence microscopy imaging
Conduct experiments to identify and validate drug targets and support assay design, optimization, validation, and data analyses in a drug discovery setting.
Locations (2)
Boston, Massachusetts, United States
Cambridge, Massachusetts, United States
Responsibilities
Plan and independently execute in vivo experiments to support preclinical characterization and evaluation of targets/pathways that regulate energy balance
Perform routine rodent handling, dosing via multiple routes of administration, blood collection, perfusion, and tissue collection
Conduct metabolic assessments, including food intake measurements, glucose tolerance tests, and insulin tolerance tests
Perform molecular and biochemical assessments on ex vivo samples
Maintain accurate records, independently analyze data, and report data in written and oral formats
Requirements
B.S. and/or M.S. in biology or a closely related field
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