- South San Francisco, California, United States
- 3+ years
Design and execute in vivo mouse studies of AAV-based cancer therapeutic candidates to advance oncology pipeline and technology platform.
Responsibilities
- Design and execute in vivo studies in various preclinical tumor models to evaluate the mechanism of action, efficacy and safety of therapeutic candidates
- Perform in vivo procedures, such as orthotopic tumor implantation, IV and IP injections, blood sampling, in vivo imaging, and animal welfare monitoring
- Perform necropsy, tissue collection and processing for IHC or histopathology, tissue dissociation and cell sorting via MACS/FACS for downstream tumor cell-based or immune cell-based assays
- Conduct immune cell profiling using multicolor flow cytometry, and cytokine/chemokine analysis using ELISA and Luminex
- Generate, document, analyze and interpret experimental data to support critical decisions on the lead candidates
Requirements
- PhD in Life Sciences with specialization in oncology or immunology
- Nice to have: GLP or regulatory-compliant environment