Research Scientist II to join the Cell Pharmacology group to develop and execute robust cell-based assays to inform screening, compound profiling, structure–activity relationships, and discovery program progression in targeted protein degradation.
The base pay range for this position at commencement of employment is expected to be between $142,474.00 and $157,472.00 annually
- Develop, optimize, validate, and execute fit-for-purpose cell-based assays for screening, hit confirmation, compound profiling, mechanism-of-action studies, and SAR progression.
- Apply HiBiT, HTRF, and CellTiter-Glo technologies to measure protein degradation, pathway modulation, viability, and related pharmacology endpoints.
- Independently culture, characterize, bank, and troubleshoot mammalian cell lines; engineer cellular models using stable or transient expression and genome-editing approaches.
- Plan rigorous experiments with appropriate controls and performance criteria; identify and resolve assay and cell-line issues.
- Process, analyze, visualize, interpret, and document screening and pharmacology data; translate findings into recommendations for compound and project decisions.
- PhD in cell biology, molecular biology, cancer biology, pharmacology, biotechnology, or a related discipline
- Nice to have: biotechnology industry
- Nice to have: pharmaceutical industry
- Nice to have: small-molecule drug discovery
- Nice to have: targeted protein degradation
Scientist II, Cell PharmacologyC4 Therapeutics Inc · Watertown, US
Senior Research TechnicianBexorg · New Haven, US