Principal / Sr. Principal Scientist - Molecular Biology & Protein Expression (PM schedule)
Lilly · Posted Nov 10, 2026
- San Diego, California, United States
- On-site
- Contract · Principal
- $72K–$189K per year
- 5+ years
The Principal Scientist / Senior Principal Scientist in Molecular Biology & Protein Expression will join a centralized molecular biology and protein expression platform team within Lilly Small Molecule Discovery (LSMD).
Compensation
The anticipated wage for this position is $72,000 - $189,200
Responsibilities
- Independently design and execute molecular cloning strategies
- Perform small-scale expression of recombinant proteins across multiple host systems
- Execute large-scale expression of recombinant proteins in E. coli and insect cells
- Assess expression and small-scale material using SDS-PAGE, Western blot, capillary electrophoresis, analytical SEC, and UV spectroscopy
- Develop and improve platform workflows, including parallelization, standardization, and automation of cloning and expression screening
Requirements
- B.S. or M.S. in Biological Sciences, Biochemistry, Molecular Biology, Chemistry, Biophysics, or a related discipline
- Nice to have: yeast expression
- Nice to have: large-scale mammalian expression
- Nice to have: membrane protein expression
- Nice to have: bioreactor process development