We are seeking a highly motivated Senior Scientist II with deep expertise in lipid chemistry to drive the design of novel ionizable lipids and the next generation of lipid nanoparticle (LNP) formulations for nucleic acid delivery.
Compensation
The salary range for this role is $126,000 - $181,500.
Responsibilities
Design and synthesize novel ionizable lipids, including head group, linker and tail variants, using structure-activity relationships and the pKa, biodegradability and tolerability profile of each series to guide design.
Lead the design of LNP molar compositions, optimizing the ratios of ionizable lipid, helper lipid, cholesterol and PEG-lipid (and exploring alternative or novel excipients) for potency, stability and tolerability.
Prepare LNP formulations at small scale (e.g., microfluidic or other mixing methods) to enable medium- to high-throughput screening of new lipids and compositions.
Plan and conduct formulation screening studies, defining critical formulation parameters and building structure-property relationships across lipid libraries.
Characterize lipids and LNPs using appropriate analytical methods (e.g., NMR, LC-MS, HPLC with CAD/ELSD, DLS, encapsulation and apparent pKa assays) and ensure lipid identity and purity.
Senior Scientist II with deep expertise in lipid chemistry to drive the design of novel ionizable lipids and the next generation of lipid nanoparticle (LNP) formulations for nucleic acid delivery.
Compensation
The salary range for this role is $126,000 - $181,500.
Responsibilities
Design and synthesize novel ionizable lipids, including head group, linker and tail variants, using structure-activity relationships and the pKa, biodegradability and tolerability profile of each series to guide design.
Lead the design of LNP molar compositions, optimizing the ratios of ionizable lipid, helper lipid, cholesterol and PEG-lipid (and exploring alternative or novel excipients) for potency, stability and tolerability.
Prepare LNP formulations at small scale (e.g., microfluidic or other mixing methods) to enable medium- to high-throughput screening of new lipids and compositions.
Plan and conduct formulation screening studies, defining critical formulation parameters and building structure-property relationships across lipid libraries.
Characterize lipids and LNPs using appropriate analytical methods (e.g., NMR, LC-MS, HPLC with CAD/ELSD, DLS, encapsulation and apparent pKa assays) and ensure lipid identity and purity.
Requirements
PhD in Organic Chemistry, Medicinal Chemistry, Chemical Biology, Pharmaceutical Sciences or a related field
M.S. with 8+ years of experience
Nice to have: experience with nucleic acid delivery (mRNA, DNA, siRNA)
Senior Scientist, LNP FormulationsSerif Biomedicines, Inc. · Cambridge, US
Senior Scientist, LNP FormulationsFlagship Pioneering, Inc. · Cambridge, US