Seeking a highly motivated Senior Research Associate to join the interdisciplinary cell therapy team, focused on advancing CAR-T cell therapies for solid tumors, supporting in vivo CAR-T platform preclinical development from construct screening through animal model efficacy studies.
Responsibilities
Package and titer lentivirus
Design and execute in vitro functional assays for safety and potency
Perform construct screening for CAR design
Handling and engineering human and murine T cells
Engineering and maintaining various cancer cell lines for model development
The Senior Manager, Analytical Sciences will provide scientific and technical leadership for analytical activities supporting our gene therapy product portfolio across internal and external development and testing networks.
Compensation
$150,000—$175,000 USD
Responsibilities
Serve as the analytical lead for external testing laboratories, providing scientific oversight of analytical execution, method performance, lifecycle management activities, and continuous improvement initiatives.
Develop and maintain strong working relationships with CDMO, CRO, and contract testing partners to ensure consistent method execution and analytical performance.
Lead governance activities related to analytical methods including transfers, validations, investigations, method revisions, trend monitoring, and change assessments.
Evaluate assay suitability throughout the product lifecycle and identify opportunities for optimization, modernization, or platform replacement.
Support analytical strategy and long-term control strategy development for clinical and commercial programs.
Requirements
Ph.D. in Biochemistry, Molecular Biology, Analytical Chemistry, or a related scientific discipline
M.S.
Nice to have: Experience managing analytical activities across multiple external testing organizations
Nice to have: Prior hands-on experience with CD34+ cell lineages
Senior Research Associate, Solid Tumor CAR-TNewLegend Biotech US · Philadelphia, US
Sr. Manager, Analytical SciencesGenetix Biotherapeutics · Somerville, US