Explore how neuroimmunological mechanisms drive neurodegenerative diseases across the central nervous system, peripheral nervous system, and ocular targets, driving preclinical discovery from target validation to IND readiness.
Compensation
The expected salary range for this position based on the primary location of Philadelphia, PA is $108,100 - $200,700. A discretionary annual bonus may be available based on individual and Company performance.
Responsibilities
Conceive, initiate, and execute laboratory research to advance neuroimmunology candidates from target validation to investigational new drug (IND) readiness
Investigate scientific concepts and design cutting-edge in vitro and in vivo disease models to validate novel therapeutic targets and mechanisms
Provide subject matter expertise in neuroimmunology across cross-functional discovery teams, advising on ocular and neurodegenerative research programs
Build and manage dynamic research partnerships with global internal teams, academic collaborators, and contract research organizations (CROs)
Analyze complex experimental datasets, author study reports and regulatory documentation, and present discoveries at international scientific conferences
Requirements
PhD in Immunology, Neuroscience, or a closely related biological discipline
PhD-level scientist to run preclinical pharmacology and target validation studies for neuroscience and metabolic programs, with a focus on siRNA and oligonucleotide therapeutics.
Compensation
Base Salary Range: $120,000-$160,000
Responsibilities
Design, execute, interpret, and communicate preclinical pharmacology studies, providing clear recommendations that inform program progression.
Design mechanism-of-action studies and build target-validation packages.
Establish, validate, and optimize fit-for-purpose metabolic and disease models with defined milestones and reproducibility criteria.
Evaluate efficacy, target engagement, and pharmacodynamic response of novel therapeutics.
Integrate efficacy, exposure, and PK/PD data to define exposure–response relationships and recommend next experiments.
Seeking a highly motivated Senior Research Associate to join the interdisciplinary cell therapy team, focused on advancing CAR-T cell therapies for solid tumors, supporting in vivo CAR-T platform preclinical development from construct screening through animal model efficacy studies.
Responsibilities
Package and titer lentivirus
Design and execute in vitro functional assays for safety and potency
Perform construct screening for CAR design
Handling and engineering human and murine T cells
Engineering and maintaining various cancer cell lines for model development
Senior Scientist responsible for designing, executing, and interpreting mechanistic immunology studies to support target identification and therapeutic development in livestock and companion animal programs.
Responsibilities
Design, execute, troubleshoot, and document in vitro, ex vivo, and in vivo studies that define immune mechanisms, support target identification and validation, and inform substrate or modality decisions.
Characterize immunological responses across model systems and species using fit-for-purpose technical approaches, integrating data from multiple assay formats into clear conclusions.
Develop, optimize, qualify, and transfer immunoassays across ELISA, ELISpot, MSD/U-Plex, Luminex, flow cytometry, and other relevant platforms.
Develop and adapt cell-based assays using primary and immortalized immune and non-immune cells, applying imaging, luminescence/fluorescence, receptor-binding, effector-function, and related readouts.
Plan experiments independently using literature, prior data, and input from project leads; analyze results, identify risks and next steps, and recommend practical follow-on studies.
Develop cellular assays and perform experiments to validate therapeutic targets and investigate pharmacology and mechanism of action of immune-mediated and autoimmune disease molecules.
Responsibilities
Contribute to experimental design and optimise and execute reproducible cellular immunology and pharmacology studies
Develop cell-based assays using primary immune cells and cell lines, including multiparameter flow cytometry and immune-response characterisation assays
Evaluate therapeutic hypotheses and characterise on-target and off-target biological effects of tool and candidate molecules
Analyse and interpret experimental data with appropriate attention to sensitivity, reproducibility and scientific quality
Summarise and present results, conclusions and recommendations clearly to specialist and non-specialist colleagues
Requirements
PhD in immunology, cellular biology, pharmacology or a related discipline
Nice to have: small biopharmaceutical environment
Nice to have: inflammatory disease research
Nice to have: autoimmune disease research
Nice to have: biochemical or cellular mechanism-of-action studies
Analytical Development Scientist supporting viral vector gene therapy product development.
Compensation
Compensation: $32.00-$36.00 per hour based on education and relatable industry experience.
Responsibilities
Execute analytical methods to support product characterization, process development, candidate selection, manufacturing support, and regulatory submissions.
Perform routine testing and data analysis using analytical techniques such as plate-based bioassays with flow cytometry, qPCR, ddPCR, ELISA, and endotoxin methods.
Assist with method development, optimization, qualification, and troubleshooting to improve assay performance, robustness, and reproducibility.
Prepare and maintain analytical procedures, technical reports, protocols, and laboratory documentation in accordance with departmental standards.
Collaborate with internal teams to share analytical results, investigate technical issues, and support the rollout of analytical strategies across development programs.
Requirements
B.S. in Biology, Biochemistry, Cell Biology, Molecular Biology or a related field
M.S. in Biology, Biochemistry, Cell Biology, Molecular Biology or a related field
Lead a team of analytical scientists to develop and optimize potency assays for lentiviral vector gene therapy products, ensuring robust analytical methods and supporting regulatory submissions.
Compensation
Compensation: $38.00-$46.00 per hour based on education and relatable industry and leadership experience.
Responsibilities
Develop, optimize, and qualify analytical methods with emphasis on potency assays, cell-based assays, and advanced characterization methods.
Support design and execution of experiments to improve assay performance, establish method readiness, and support analytical control strategy development.
Support analytical method transfer activities by preparing technical documentation, supporting partner training, reviewing transferred data, and troubleshooting assay performance.
Generate, analyze, and present scientific data to cross-functional stakeholders to support product characterization, process changes, comparability assessments, and regulatory submissions.
Contribute to authoring technical reports, protocols, method transfer packages, and analytical development documentation while serving as a technical resource for potency assay and analytical development activities.
Requirements
B.S. in Biology, Biochemistry, Cell Biology, Molecular Biology or a related field
M.S. in Biology, Biochemistry, Cell Biology, Molecular Biology or a related field
Provide support on biomarker studies to meet the company's goals, objectives and quality standards.
Compensation
The North Carolina salary range for this position is: $27-$31.50 per hour
Responsibilities
Responsible for cell experiments in vitro, pre‑treatment and processing of tissue samples, and execution of a variety of experiments including flow cytometry, pathology/IHC, proteomics, hematology
Carry out work in strict accordance to SOPs and training sessions
Carefully record the experimental process and data and submit timely reports to supervisors
Analyze, summarize, and report experimental data and relevant documents to supervisors
Effective communication within the global biomarker team and with other departments
Requirements
B.S. or above in biotechnology, cell biology, immunology, oncology or other related disciplines
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