Conduct advanced molecular-genetic, cell biological, and biochemical studies for a multi-year NIH-funded project.
Responsibilities
Perform designated procedures associated with experiments/projects; interpret and analyze results; multi-task experimentally as necessary, and present data in organized form.
Review up-to-date scientific literature extracting information relevant to ongoing, proposed, or possible research projects.
Learn, develop and utilize new techniques that facilitate research goals by consulting literature or other University personnel including faculty, students and research assistants.
Provide written and oral progress reports to supervisor and research group.
Carry out genetic manipulation in the C. elegans model system including conducting genetic crosses, transgenics requiring microinjections, and CRISPR/Cas9 methods.
Requirements
Ph.D. with dissertation focusing on molecular genetic, biochemical, and cell biological approaches using model organisms
Lead a scientific team in protein production, purification, and characterization to support discovery and early development of biotherapeutics.
Compensation
Per Year Salary Range
$160,000—$210,000 USD
Responsibilities
Oversee production across mammalian, bacterial, and cell-free systems, including end-to-end workflows for construct design, expression, purification, characterization, quality control, normalization, and assay-ready handoff.
Drive innovation for difficult antigens and complex proteins through construct and boundary optimization, tag and format selection, alternate expression systems, site-specific labeling, automation, and other enabling technologies.
Establish fit-for-purpose production, purification, and characterization standards for attributes including yield, purity, aggregation, concentration, identity, oligomeric state, stability, and biotinylation.
Lead portfolio planning, prioritization, and resource allocation for the team across internal and outsourced production and characterization activities.
Manage relationships with CROs, technology providers, and other external partners, and communicate progress, risks, resource needs, and tradeoffs to senior stakeholders.
Requirements
PhD in biochemistry, molecular biology, chemical engineering, bioengineering, protein sciences, or a related discipline
As a Senior Research Scientist 1, you take part in the scientific leadership of the company through mentoring, consensus building, and technical expertise in multiple areas of specialization. You propose, execute, and champion innovative research and product development. You set the overall project strategy for experimental design, drawing on your experimental results and the scientific literature. In this role, you will contribute to ongoing high-priority projects and serve as the technical lead on development of new assays, from conception to catalog launch. You will also serve as the group’s subject-matter expert in structural biology and/or protein purification.
Responsibilities
Primary author for contributions to internal technical literature, abstracts, patents, or journal articles
Contribute to preparation or evaluation of patents
Mentor and/or direct others on a designated project
Independently develop project plans and manage project timelines
Recognized as scientific expert in multiple areas of specialization and provide scientific leadership
Requirements
PhD degree in biochemistry, structural biology, or a related field
Senior Research Associate in Wilsonville, Oregon, to help new products and process improvements, with a particular focus on supporting orders ahead of full integration and scale.
Responsibilities
Independently design, execute, and troubleshoot experiments
Support the build-out and vetting of new processes ahead of launch
Perform manual experiments with the intention of automating them for production processing of new or in-development workflows
Identify process gaps, bottlenecks, and risks before they reach manufacturing, and help implement optimizations
Serve as a vigilant check on process quality, catching inconsistencies or at-risk steps and raising them before they affect downstream production or customer orders
Requirements
B.S. in Molecular Biology, Biochemistry, Chemistry, or a closely related field
Seeking an enthusiastic, dynamic and self-motivated lab-based scientist to join the Antibody Protein Expressions team, accountable for V-gene cloning and expression of antibody molecules from early Hit-Panels through to optimised panels for developability profiling.
Locations (2)
Stevenage, Hertfordshire, United Kingdom
Cambridge, England, United Kingdom
Responsibilities
Ensure timely delivery of high-quality, well-characterised protein to programme teams
Represent the Antibody Protein Expression team within matrix groups working towards developing therapeutic antibodies
Prepare and deliver verbal and written scientific communications
Line manage a sub-team of scientists, taking responsibility for their day-to-day management, wellbeing and development
Proactively manage the performance of line reports
Requirements
PhD (or equivalent) in biochemistry, molecular biology, protein engineering, biotechnology or a related discipline
Postdoc in microbial production of self-assembling protein materials - BRIGHT
Internship focused on implementing nanodisc technology for membrane protein screening and characterization within Genmab’s Discovery Preparation and Humanization team.
Compensation
The proposed gross annual base salary range for this position, in the primary location, based on a full time schedule is: EUR750,00---750,00
Responsibilities
Optimize cell culturing and lysis protocols
Set up automated screening and purification of Nanodiscs
Analyze and characterize the behavior of various membrane protein topologies using biochemical and biophysical techniques
Apply these materials in use cases within the wider Discovery organization
Report and present progress and findings to multiple stakeholders
Requirements
HBO or Master’s degree program in Molecular Biology, Life Sciences, Biomedical Sciences, or related field
Conduct purification and analytical testing using large-scale lab equipment, while supporting lab operations, documentation, and cross-functional collaboration.
Responsibilities
Protein purification
Buffer preparation & formulation
Column packing
Tangential Flow Filtration (TFF)
Sample management (aliquot preparation)
Requirements
Bachelor's degree in Science or other related degree concentration
As a CMC purification development scientist, you will independently design, execute, and interpret experiments to develop robust, phase-appropriate purification processes for drug substance GMP production to enable human clinical studies and eventual licensure.
Responsibilities
Develop, optimize, and scale up purification processes for monoclonal antibodies, multi-specifics, antibody-like molecules, and other complex biologic candidates across early- and late-stage drug substance process development
Support transfer of purification processes to GMP manufacturing sites for clinical material production, including preparation of technical documentation
Evaluate novel, advanced bioprocess technologies that are in line with the group’s strategy
Plan and execute laboratory and scale-up activities efficiently, collaborating within the team and cross-functionally to meet project timelines and goals
Work with contract laboratories to plan and execute assigned viral clearance studies, interpret results, and contribute to technical documentation
Requirements
Bachelor’s degree in Chemical Engineering, Biochemistry, Chemistry, or a closely related field
Master’s degree in Chemical Engineering, Biochemistry, Chemistry, or a closely related field
Nice to have: resin chromatography (affinity, CEX, AEX, MMC)
Post Doc Res Assoc - Molecular Biology - (Fay Lab)NewUniversity of Wyoming · Laramie, US
Associate Director, Biotherapeutic Production and CharacterizationNewGenerate Biomedicines · Somerville, US
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Postdoc in microbial production of self-assembling protein materials - BRIGHTNewDTU · Kgs. Lyngby, Denmark
Intern, Discovery Preparation & Humanization (Project: Implementation of automated Nanodisc screening and characterization)Genmab · Utrecht, Netherlands