Senior Bioinformatics Scientist
Ephla Bio · Posted Oct 29, 2026
- Toronto, Ontario, Canada +2 more
- On-site
- Full-time · Senior
Ephla Bio is looking for a bioinformatician to turn biological and experimental data into insights that guide therapeutic development. Build reproducible analysis pipelines, interpret complex datasets, and apply statistical methods to target prioritization.
Locations (3)
- Toronto, Ontario, Canada
- San Francisco Bay Area, California, United States
- New York, New York, United States
Responsibilities
- Build and validate workflows from tumor/normal sequencing (WES/WGS, RNA-seq) through QC, somatic variant calling, VAF and clonality analysis (truncal vs. subclonal, adjusted for purity and copy number), HLA typing, expression quantification, and reporting.
- Analyze HTS data and other large-scale screens. Integrate them with public datasets (e.g. immunopeptidomics) and turn patterns into testable hypotheses.
- Assess assay quality, batch effects, and biological variability. Benchmark methods, validate findings against independent datasets or experimental results, and communicate uncertainty early.