Provide hands‑on experimental and operational support for gene therapy downstream process development, including purification, filtration, chromatography, and batch execution.
Responsibilities
Plan, execute, and analyze assigned experiments
Perform downstream process operations such as depth filtration, chromatography, and TFF
Support pilot and large‑scale batch execution
Compile and analyze experimental data
Document procedures and results
Requirements
Bachelor’s degree in biological sciences, pharmaceutical sciences, chemical engineering, or a related technical field
Execute assigned experimental and process activities in support of defined program deliverables, working under the guidance of senior team members.
Compensation
Pay: $35-38/hr.
Responsibilities
Perform hands-on downstream process operations, such as depth filtration, chromatography, and/or tangential flow filtration (TFF), at both small and large scale.
Support the execution of pilot- and large-scale batches, including equipment and materials preparation, process operation, sampling, and documentation.
Compile, analyze, and summarize experimental data and share results and observations with the team.
Accurately document experimental procedures, observations, and results in accordance with good documentation practices.
Prepare and maintain laboratory equipment, buffers, and materials, and help coordinate laboratory activities and supplies for assigned studies.
Global Manufacturing Technology (GMT) is seeking a hands‑on, postdoctoral‑level scientist to improve the potency and yield of a Mycoplasma fermentation process.
Responsibilities
Plan and lead upstream studies to improve Mycoplasma fermentation performance, with emphasis on product potency and process yield.
Design and execute bench‑scale fermentation experiments; evaluate relevant process variables and use structured experimental approaches to identify key drivers of performance.
Operate and troubleshoot laboratory bioreactors and maintain appropriate aseptic technique and process documentation.
Characterize fermentation outcomes using appropriate growth, process, yield, and potency measurements; analyze results and communicate clear recommendations.
Optimize and assess downstream recovery steps, including depth filtration and chromatography, and understand how upstream conditions affect downstream performance and product quality.
Requirements
PhD in microbiology, biotechnology, biochemistry, biological engineering, chemical engineering, or a related discipline; candidates with a master’s degree and 5+ years of directly relevant experience may also be considered.
Plan and lead upstream studies to improve Mycoplasma fermentation performance, with emphasis on product potency and process yield.
Design and execute bench-scale fermentation experiments; evaluate relevant process variables and use structured experimental approaches to identify key drivers of performance.
Operate and troubleshoot laboratory bioreactors and maintain appropriate aseptic technique and process documentation.
Characterize fermentation outcomes using appropriate growth, process, yield, and potency measurements; analyze results and communicate clear recommendations.
Optimize and assess downstream recovery steps, including depth filtration and chromatography, and understand how upstream conditions affect downstream performance and product quality.
Requirements
PhD
Master's degree
Nice to have: Postdoctoral research experience
Nice to have: Mycoplasma cultivation or fermentation
Dedicated professional to drive purification process development for gene therapy assets, focusing on AAV and LVV modalities.
Compensation
Competitive salary commensurate with experience
Responsibilities
Execute assigned experimental and process activities in support of defined program deliverables, working under the guidance of senior team members.
Perform hands‑on downstream process operations, such as depth filtration, chromatography, and/or tangential flow filtration (TFF), at both small and large scale.
Support the execution of pilot‑ and large‑scale batches, including equipment and materials preparation, process operation, sampling, and documentation.
Requirements
Bachelor’s degree in biological sciences, pharmaceutical sciences, chemical engineering, or a related technical field with 2 years of relevant experience; or Master’s degree with 0–1 years of relevant experience.
Nice to have: pilot‑ or large‑scale batch execution
Provide hands‑on experimental and operational support for gene therapy downstream process development, including purification, pilot and large‑scale batch execution, data analysis, and documentation.
Responsibilities
Execute assigned experimental and process activities
Perform downstream process operations such as depth filtration, chromatography, and/or tangential flow filtration
Support pilot and large‑scale batch execution
Compile, analyze, and summarize experimental data
Document procedures and results
Requirements
Bachelor’s degree in biological sciences, pharmaceutical sciences, chemical engineering, or a related technical field
Master’s degree with 0–1 years of relevant experience
Lead the design, buildout, and execution of upstream and downstream capabilities within our Biologics Research organization to expand what’s possible for patients with serious diseases.
Compensation
Pay Range:
$185,000.00-252,500.00 Annual
Responsibilities
Build, lead, and mentor a high-performing research bioprocess development team
Establish a collaborative, accountable, and scientifically rigorous team culture
Set priorities and allocate resources across multiple concurrent programs
Design and oversee the buildout of new state-of-the-art research bioprocess development laboratories
Define equipment strategy and select platforms for upstream processing (USP) and downstream processing (DSP)
Requirements
PhD in chemical engineering, biochemical engineering, biology, or related field
Seeking an innovative Scientist in the Purification Development group developing downstream processes for mAbs, bispecifics, enzymes, recombinant proteins, Fc fusions, etc.
Compensation
The base compensation range for this role is $75,000-$80,000.
Responsibilities
Support the development, optimization, and validation of purification workflows as well as process transfers to and from client sites.
Develop appropriate tools and technologies to enable right at first pass scale-up and technology transfer.
Supporting multiple client projects in parallel for protein purification.
Work with senior leadership on developing downstream purification processes for client projects.
Generate ideas for continuous improvement and innovative internal capabilities.
Requirements
BS in Biological Sciences
MS in Biological Sciences
Nice to have: JMP statistics
Nice to have: DoE setup
Nice to have: Experience in managing or contributing to multiple projects
Associate Scientist II, PD DownstreamCelgard · Fremont, US