Lead Scientist in Computational Drug Discovery, executing structure-guided design and computational analyses to support drug discovery projects from early hits through lead selection.
Locations (2)
Copenhagen, Capital Region, Denmark
Boston, Massachusetts, United States
Responsibilities
Co-develop discovery hypotheses and molecular design strategies together with experimental colleagues
Provide structure-guided analysis and actively participate in drug discovery projects, from early hits to lead selection
Generate de novo hits and optimize existing hits with computational methods
Develop and maintain computational workflows within the computational drug discovery pipeline
Develop and maintain computational tools for the Discovery Research organization
Requirements
PhD in Computational Chemistry
PhD in Bioinformatics
PhD in Computational Biology
Nice to have: AI-based peptide and protein structure prediction and design methodologies
Nice to have: Machine learning predictive models for drug property prediction
Execute structure-guided design and computational analyses with a focus on immediate deliverables and operational objectives, using advanced analytical and technical skills to support drug discovery projects from early hits through lead selection.
Locations (2)
Copenhagen, Capital Region, Denmark
Boston, Massachusetts, United States
Responsibilities
Co-develop discovery hypotheses and molecular design strategies together with experimental colleagues
Provide structure-guided analysis and actively participate in drug discovery projects, from early hits to lead selection
Generate de novo hits and optimize existing hits with computational methods
Develop and maintain computational workflows within the computational drug discovery pipeline
Develop and maintain computational tools for the Discovery Research organization
The Associate Director, Medicinal Chemistry is a research leader who defines and advances medicinal chemistry strategy for oncology drug-discovery programs. The role applies deep expertise in medicinal chemistry and small-molecule design to translate biological hypotheses into differentiated compounds, integrates seamlessly across project teams and functions, and leads project execution with guidance from senior leaders.
Locations (2)
Boston, Massachusetts, United States
France
Compensation
The salary range for this role is $170,000 - $201,000. Employees in this position are also eligible for Short-Term and Long-Term incentive programs.
Responsibilities
Lead medicinal chemistry strategy for one or more discovery programs, from hit identification and validation through lead optimization and candidate nomination.
Define compound-design hypotheses and decision criteria by integrating structure–activity relationships, structural biology, computational chemistry, biophysics, pharmacology, DMPK/ADME, safety, and developability data.
Conceive, prioritize, and oversee the synthesis and testing of compounds that address potency, selectivity, physicochemical properties, pharmacokinetics, safety liabilities, and translational requirements.
Co-lead multidisciplinary project teams with guidance from senior leaders; align scientific objectives, key experiments, milestones, risks, and recommendations across functions.
Integrate seamlessly across multiple project teams and functions, communicate complex chemistry and drug-discovery concepts clearly, and represent Chemistry in governance and portfolio discussions as assigned.
Requirements
PhD in medicinal chemistry, organic chemistry, or a closely related discipline
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