Upstream process development jobs

Senior Scientist – Upstream Process Development (Temporary Maternity Cover)

AstraZeneca · Posted Nov 4, 2026

Cambridge, Cambridgeshire, United Kingdom
On-site
Temporary · Senior

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A Senior Scientist role responsible for hands-on scientific delivery of upstream cell culture process activities supporting biologics pipeline, focusing on process development, scale-up, and technology transfer within a matrix environment.

Responsibilities

Deliver assigned upstream process development activities across CMC cycles
Perform and contribute to the design and interpretation of mammalian cell culture studies using CHO cells, including cryopreservation, revival, inoculum expansion, fed-batch and perfusion processes
Operate high-throughput and bench-scale bioreactor platforms including ambr systems and stirred-tank bioreactors
Apply Design of Experiments (DoE) and multivariate analysis to identify process drivers
Assess cell growth, viability, metabolism, productivity, and culture stability

Requirements

Biochemical engineering
Bioprocessing
Biotechnology
Biology
Nice to have: PhD or Master's degree

Skills

Mammalian cell culture Upstream process development CHO cell culture Aseptic technique

Manager, Upstream Pilot Plant

Manager, Upstream Pilot Plant

Compensation

Responsibilities

Requirements

Skills

Benefits

Senior Scientist – Upstream Process Development (Temporary Maternity Cover)

Responsibilities

Requirements

Skills