Scientist/Sr. Scientist, Pre-clinical Pharmacology (Neuroscience & Metabolism)
Manifold Bio · Posted Nov 13, 2026
- Boston, United States
- On-site
- Full-time · Senior
- $120K–$160K per year
- 1–6 years
PhD-level scientist to run preclinical pharmacology and target validation studies for neuroscience and metabolic programs, with a focus on siRNA and oligonucleotide therapeutics.
Compensation
Base Salary Range: $120,000-$160,000
Responsibilities
- Design, execute, interpret, and communicate preclinical pharmacology studies, providing clear recommendations that inform program progression.
- Design mechanism-of-action studies and build target-validation packages.
- Establish, validate, and optimize fit-for-purpose metabolic and disease models with defined milestones and reproducibility criteria.
- Evaluate efficacy, target engagement, and pharmacodynamic response of novel therapeutics.
- Integrate efficacy, exposure, and PK/PD data to define exposure–response relationships and recommend next experiments.
Requirements
- PhD in Pharmacology
- PhD in Neuroscience
- PhD in Physiology
- PhD in Endocrinology
- PhD in Biology