Mammalian upstream process development jobs

Senior Scientist – Upstream Process Development (Temporary Maternity Cover)

AstraZeneca · Posted Nov 4, 2026

Cambridge, Camshire, United Kingdom
On-site
Temporary · Senior

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Responsible for the hands-on scientific and technical delivery of upstream mammalian cell culture process development activities supporting AstraZeneca’s biologics pipeline.

Responsibilities

Deliver assigned upstream process development activities across CMC development cycles.
Perform and contribute to the design and interpretation of mammalian cell culture studies using CHO-based systems.
Execute cryopreservation, revival, inoculum expansion, fed-batch and perfusion processes.
Operate high-throughput and bench-scale bioreactor platforms including ambr systems and stirred-tank bioreactors.
Apply Design of Experiments, multivariate analysis, and statistical approaches to identify process drivers.

Requirements

BSc/MSc/PhD in biochemical engineering
bioprocessing
biotechnology
biology
related scientific discipline

Skills

mammalian upstream process development CHO cell culture aseptic cell culture bioreactor-system operation Design of Experiments (DoE)