Principal Scientist – Oligonucleotide & AOC Analytical Chemistry
Atrium Therapeutics · Posted Nov 6, 2026
- San Diego, California, United States
- Full-time · Senior
- $185K–$205K per year
- 8+ years
Lead analytical characterization of antibody-oligonucleotide conjugates (AOCs) and develop phase-appropriate analytical methods for drug substance, product, and intermediates.
Compensation
The base salary range for this role is $185,000-$205,000. The final compensation will be commensurate with such factors as relevant experience, skillset, internal equity and market factors.
Responsibilities
- Lead efforts to build internal analytical capabilities and laboratory infrastructure.
- Develop, optimize, qualify, and transfer analytical methods for AOCs, oligonucleotide intermediates, and related materials.
- Design and execute forced-degradation and development stability studies; elucidate degradation pathways for both the antibody and oligonucleotide components.
- Serve as analytical lead and provide in-process and release-type analytical testing of oligonucleotides and conjugates in support of discovery, process development, and GLP studies.
- Partner with oligonucleotide and AOC bioconjugation teams to develop analytical methods to characterize and quantify process intermediates and impurities.
Requirements
- Ph.D. in analytical chemistry, biochemistry, chemistry or a related field
- M.S. with 12+ years
- B.S. with 14+ years