Support development of recombinant therapeutic antibody drug candidates through development, optimization, qualification, and transfer of analytical methods used for characterization of investigational products.
Compensation
The estimated pay scale for Scientist I ( Analytical Development) role based in California, is $100,412 - $120,515 per year. Additionally, the position is eligible to participate in up to 8% of the company bonus pool.
Responsibilities
Plan and perform various analytical techniques, including SE-HPLC, SEC-MALS, CEX-HPLC, cIEF, SDS-PAGE, CE-SDS, ELISA, MSD, in vitro cell-based assays, and qPCR
Analyze, interpret, and present analytical data to drive technical understanding, meet project objectives, troubleshoot, and make recommendations
Discuss experimental plans and results with project team members
Develop, write, and review technical documents such as analytical test methods, method qualification protocols, and method qualification reports
Collaborate and coordinate activities across functional groups involved in antibody therapeutics development, including discovery, process development, and project management teams
Lead analytical characterization of antibody-oligonucleotide conjugates (AOCs) and develop phase-appropriate analytical methods for drug substance, product, and intermediates.
Compensation
The base salary range for this role is $185,000-$205,000. The final compensation will be commensurate with such factors as relevant experience, skillset, internal equity and market factors.
Responsibilities
Lead efforts to build internal analytical capabilities and laboratory infrastructure.
Develop, optimize, qualify, and transfer analytical methods for AOCs, oligonucleotide intermediates, and related materials.
Design and execute forced-degradation and development stability studies; elucidate degradation pathways for both the antibody and oligonucleotide components.
Serve as analytical lead and provide in-process and release-type analytical testing of oligonucleotides and conjugates in support of discovery, process development, and GLP studies.
Partner with oligonucleotide and AOC bioconjugation teams to develop analytical methods to characterize and quantify process intermediates and impurities.
Requirements
Ph.D. in analytical chemistry, biochemistry, chemistry or a related field
Senior Research Scientist/Engineer leading CMC development and operations for protein therapeutics and nanoparticle vaccines at the Institute for Protein Design.
Compensation
Pay Range Minimum: $150,000.00 annual
Pay Range Maximum: $175,008.00 annual
Responsibilities
Own CMC development strategy and sequencing
Coordinate with Core R&D Lead for Process Development
Support integrated development timelines and budgets
Assess manufacturability of research-stage candidates
Provide design input for preclinical studies
Requirements
Ph.D. in biochemistry, bioengineering, chemical engineering, or related field
Lead antigen strategy and membrane protein work for target discovery, assessment, validation, and tractability in support of therapeutic discovery programs.
Locations (2)
Bothell, Washington, United States
Princeton, New Jersey, United States
Compensation
The expected base salary range for this position is $110,000 - $130,000 annually.
Responsibilities
Contribute to target discovery, assessment, and validation efforts for membrane protein targets, with a focus on GPCRs, including evaluating target tractability from a protein science perspective.
Design and execute antigen strategies, including construct design, protein purification, and format selection, to maximize the probability of generating useful binders and functional data.
Engineer membrane protein antigens and alternative antigen formats (e.g., nanodiscs, liposomes, stabilized conformations, and cell-based presentation) to support diverse discovery platforms.
Design and implement purification and quality control workflows for detergent-solubilized and alternative antigen formats, ensuring high purity, protein integrity, and native-like conformation.
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