Work in a manufacturing laboratory setting using mammalian cell culture practices and techniques. Understand, follow, and complete process documentation in support of GMP. Understand and follow safety policies as it relates to biological and chemical components and equipment to protect personnel and maintain product quality.
Responsibilities
Perform processes and operate equipment required for production of bulk viral antigen
Understand and apply good cell culture practices as it relates to viral and antibody production
Operate equipment involved in downstream processing of production bulk fluids (e.g., tangential flow filtration, hollow-fiber filtration, sterile filtration, etc.)
Using knowledge of bioreactors/fermentors and support equipment, apply skills to identify mechanical problems and maintain equipment
Understand, follow, and complete process documentation in support of GMP
Requirements
High school degree or equivalent
BS in Biological sciences
Nice to have: BS in Biological sciences
Nice to have: Relevant experience in biological production and/or aseptic manufacturing
The Process Development scientist will develop, optimize, and scale downstream purification processes for biologics, including viral vectors and bacteriophages, to support client programs and manufacturing technology transfer.
Locations (2)
College Station, Texas, United States
Bryan, Texas, United States
Responsibilities
Execute downstream studies in clarification, chromatography, ultrafiltration/diafiltration and final filtration; analyze recovery, impurity clearance and process performance, and propose solutions.
Author or assist with protocols, SOPs, process descriptions, technical reports and manufacturing batch record content.
Present findings to team members, leadership and clients as appropriate to level.
Independently design and lead studies, troubleshoot processes and train colleagues (forist II/III).
Serve as a downstream technical SME, assess client processes for GMP suitability and scale-up needs, and lead downstream technology transfer (for Scientist III).
Execute assigned experimental and process activities in support of defined program deliverables, working under the guidance of senior team members.
Compensation
Pay: $35-38/hr.
Responsibilities
Perform hands-on downstream process operations, such as depth filtration, chromatography, and/or tangential flow filtration (TFF), at both small and large scale.
Support the execution of pilot- and large-scale batches, including equipment and materials preparation, process operation, sampling, and documentation.
Compile, analyze, and summarize experimental data and share results and observations with the team.
Accurately document experimental procedures, observations, and results in accordance with good documentation practices.
Prepare and maintain laboratory equipment, buffers, and materials, and help coordinate laboratory activities and supplies for assigned studies.
Dedicated professional to drive purification process development for gene therapy assets, focusing on AAV and LVV modalities.
Compensation
Competitive salary commensurate with experience
Responsibilities
Execute assigned experimental and process activities in support of defined program deliverables, working under the guidance of senior team members.
Perform hands‑on downstream process operations, such as depth filtration, chromatography, and/or tangential flow filtration (TFF), at both small and large scale.
Support the execution of pilot‑ and large‑scale batches, including equipment and materials preparation, process operation, sampling, and documentation.
Requirements
Bachelor’s degree in biological sciences, pharmaceutical sciences, chemical engineering, or a related technical field with 2 years of relevant experience; or Master’s degree with 0–1 years of relevant experience.
Nice to have: pilot‑ or large‑scale batch execution
Provide hands‑on experimental and operational support for gene therapy downstream process development, including purification, pilot and large‑scale batch execution, data analysis, and documentation.
Responsibilities
Execute assigned experimental and process activities
Perform downstream process operations such as depth filtration, chromatography, and/or tangential flow filtration
Support pilot and large‑scale batch execution
Compile, analyze, and summarize experimental data
Document procedures and results
Requirements
Bachelor’s degree in biological sciences, pharmaceutical sciences, chemical engineering, or a related technical field
Master’s degree with 0–1 years of relevant experience
Lead development and optimization of downstream purification processes supporting viral vector programs from research through preclinical development.
Compensation
$72,000 - $189,200
Responsibilities
Lead development, optimization, and scale-up of downstream purification workflows for viral vectors.
Design and implement purification strategies using Iodixanol and CsCl density gradient ultracentrifugation, affinity chromatography, ion-exchange chromatography (AEX/CEX), membrane chromatography, and polishing operations.
Lead AKTA-based chromatography workflow development and process intensification initiatives.
Develop scalable downstream platform approaches to support rapid material generation and process consistency across programs.
Independently design experiments, analyze data, interpret results, and present technical conclusions to multi-functional teams and leadership.
Requirements
Bachelor’s degree in biology, biochemistry, chemical engineering, biotechnology, or related scientific field
Master’s/PhD
Nice to have: CsCl and iodixanol ultracentrifugation
Support Molecular Biology Conversion manufacturing in a cGMP regulated environment, performing oligonucleotide manufacturing activities, maintaining records, and ensuring compliance with quality systems.
Locations (3)
Petaluma, California, United States
Novato, California, United States
Denmark
Compensation
The typical pay range for this role is: Minimum: $ 20.91/ Hourly Maximum: $ 34.855/ Hourly
Responsibilities
Perform oligonucleotide manufacturing activities according to protocols
Maintain accurate batch records and equipment logs
Conduct basic laboratory tasks and analytical measurements
Assist with troubleshooting, maintenance and calibration of equipment
Maintain a clean and safe laboratory environment
Senior Research Associate Biologics/Bioconjugation
Senior Research Associate to support development of targeted lipid nanoparticle (tLNP) conjugation and purification in a lab-based research team
Compensation
$74,800 - $112,200
Responsibilities
Execute routine conjugations of various ligands, scaffolds, and peptides to LNPs using established and emerging methods
Assist with the development, optimization, and troubleshooting of tLNP conjugation and purification processes at bench and pilot scales
Analyze tLNP critical quality attributes using techniques such as Dynamic Light Scattering (DLS), RiboGreen assays, HPLC, and related analytical methods
Participate in planning of experiments and may perform some experiments with limited supervision
Analyze experimental data, maintain detailed records in ELNs, and prepare summaries and presentations for internal team discussions
Requirements
Bachelor's Degree in biological sciences
Master's Degree in biological sciences
Nice to have: Antibody drug conjugates
Nice to have: Antibody oligonucleotide conjugation
Bachelor’s degree in a relevant scientific or engineering discipline, such as Biology, Biochemistry, Microbiology, Biotechnology, Chemical Engineering or Bioengineering
Nice to have: purifying products from bacterial or other microbial processes
Nice to have: membrane processing
Nice to have: host-cell impurity/endotoxin removal
Process Development Scientist - DownstreamMatica Biotechnology, Inc. · College Station, US+1 more
Associate Scientist - Downstream Process DevelopmentLilly · Boston, US