Yeast surface display jobs

Scientist II, Molecular Function

Profluent · Posted Nov 6, 2026

Emeryville, California, United States
On-site
Full-time · Mid
$155K–$160K per year
3+ years

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Profluent is hiring a Scientist II to build and own their yeast surface display platform for binder generation, producing data to train and evaluate protein design models.

Compensation

$155,000—$160,000 USD

Responsibilities

Establish and validate a yeast surface display platform for binder generation, including display vector and strain selection, library design and construction, and FACS-based selection and sorting
Design and execute yeast display campaigns across binder formats (e.g., de novo miniproteins, VHHs, scFvs, and alternative scaffolds) against a range of targets
Take workflows from concept to a robust, repeatable process: define controls, QC, and acceptance criteria, and characterize reproducibility, signal-to-noise, and the relationship between sort-bin enrichment and binding strength
Build NGS readouts into selections and deep mutational scanning workflows, converting raw sequencing counts into quantitative binding metrics that ML models can learn from
Partner with the ML scientists, and Protein Design scientists to scope campaigns (targets, library composition, readouts) and to define what 'model-ready' binding data looks like

Requirements

PhD in Molecular Biology
Biochemistry
Protein Engineering
Biophysics
Immunology

Senior Research Associate – High Throughput Screening and Assay Development

Senior Research Associate – High Throughput Screening and Assay Development

Responsibilities

Requirements

Skills

Scientist II, Molecular Function

Compensation

Responsibilities

Requirements

Skills

Benefits